Definitions

1. Bordetella parapertussis is a related organism and causes a similar, but milder, disease.
2. Bordetella parapertussis is a Gram-negative bacterium which colonizes the human respiratory tract and can cause whooping cough or pertussis. (Web site)
3. However, B. parapertussis is able to reach high levels in the LRT without this toxin. (Web site)
4. Bordetella parapertussis is a small Gram-negative bacterium of the genus Bordetella which is adapted to colonise the mammalian respiratory tract.
5. Bordetella parapertussis is a respiratory pathogen that can cause mild pharyngitis. (Web site)

Clonal

1. Clinical isolates of B. parapertussis from humans are essentially clonal and appear to have diverged from B. bronchiseptica relatively recently (27). (Web site)

Pertussis Infections

1. The role of distal LPS structures in B. parapertussis and B. pertussis infections appears to be substantially different from that in B. bronchiseptica. (Web site)

Tlr4-Deficient Mice

1. While B. bronchiseptica causes lethal disease in TLR4-deficient mice, B. pertussis and B. parapertussis do not. (Web site)

Bpze1

1. Moreover, BPZE1 protected against Bordetella parapertussis infection, whereas aPV did not. (Web site)

Bordetella Parapertussis Infections

1. Although Bordetella pertussis is considered the main causative agent of whooping cough in humans, Bordetella parapertussis infections are not uncommon.

Related

1. B. parapertussis (B.pp), closely related to B.p, also causes whooping cough. (Web site)

Human

1. Differentiation between human and ovine isolates of Bordetella parapertussis using pulsed-field gel electrophoresis.
2. Human but not ovine isolates of Bordetella parapertussis are highly clonal as determined by PCR-based RAPD fingerprinting. (Web site)

Hypothesis

1. These findings support a hypothesis that LPS modifications by B. pertussis and B. parapertussis facilitated adaptation to humans. (Web site)

Contrast

1. In contrast, B. pertussis and B. parapertussis infect humans.

Classification

1. Pulsed-field gel electrophoresis therefore appears to be a powerful discriminatory tool for the classification of B. parapertussis. (Web site)

Evolution

1. However, gene acquisition appears to have been a rare event in the evolution of B. pertussis and B. parapertussis from B. bronchiseptica complex I [ 10]. (Web site)
2. Evolution of the B. bronchiseptica -derived host restricted-pathogens B. pertussis and B. parapertussis was dominated by substantial gene decay and loss.

Positive

1. Two specimens negative for B. pertussis by the conventional PCR assay were positive for B. parapertussis by the LC-PCR-IS assay.

Characteristic

1. In contrast with B. pertussis infection, lymphocytosis is not a characteristic of B. parapertussis infection.

Analysis

1. Our analysis indicates that B. parapertussis and B. pertussis are independent derivatives of B. bronchiseptica-like ancestors. (Web site)

Severe

1. Illness caused by B. parapertussis was typical of pertussis but less severe than that caused by B. pertussis.

Results

1. The results suggested the presence of multiple fimbrial subunit genes in B. pertussis, B. bronchiseptica and B. parapertussis. (Web site)

Vitro

1. B. bronchiseptica LPS induces greater inflammatory responses in vitro than LPSs from B. pertussis and B. parapertussis. (Web site)

Result

1. The asymmetrical cross-immunity appeared to be the result of inefficient binding of B. pertussis -induced antibodies to B. parapertussis. (Web site)

Isolation

1. Selective medium for the isolation of bordetella pertussis and parapertussis. (Web site)
2. Moredun Bordetella Medium, an improved selective medium for isolation of Bordetella parapertussis. (Web site)

Detection

1. All of these characteristics represent a significant improvement in the detection of B. pertussis and B. parapertussis in nasopharyngeal specimens.

Required

1. Genes of the wbm locus are required for the assembly of O antigen on the animal pathogen Bordetella bronchiseptica and the human pathogen B. parapertussis.

Cells

1. Here we show that clearance of B. parapertussis from the LRT similarly requires Abs, T cells, and PMNs. (Web site)

Antibodies

1. Levels of antibodies against B. pertussis and against B. parapertussis.

Vaccine

1. These data are important with respect to efforts to produce a vaccine that is effective not only against B. pertussis but also against B. parapertussis.

Discrimination

1. Detection and discrimination of B. pertussis and B. parapertussis.

Primers

1. Discrimination of amplified DNA derived from the internal control, B. pertussis, or B. parapertussis was accomplished by differential spacing of the primers. (Web site)

Study

1. Such a phenomenon might be related to the cross-reaction of IgA against B. pertussis and B. parapertussis in our study.

Assay

1. A further strength of this assay is that it detects and differentiates B. pertussis and B. parapertussis.

Lower Respiratory Tract

1. The present study explores the mechanism by which B. parapertussis is cleared from the lower respiratory tract by anamnestic immunity. (Web site)

Species

1. Bordetella wild type strains according to the present invention are selected among the species B. pertussis, B. parapertussis and B. bronchiseptica. (Web site)
2. Immunity induced by B. parapertussis infection protected against subsequent infections by either species. (Web site)

Human Pathogens

1. Three species are human pathogens (B. pertussis, B. parapertussis, B. bronchiseptica); one of these (B. bronchiseptica) is also motile. (Web site)

Incidence

1. Therefore the use of BPZE1 should also have an impact on the incidence of whooping cough caused by B. parapertussis in infants. (Web site)

Pertussis Vaccines

1. Pertussis vaccines have decreased the incidence of whooping cough, but they may have little or no efficacy against B. parapertussis (6, 7, 9, 10, 17, 22).
2. Our results suggest that pertussis vaccines are not useful for protection against B. parapertussis infection.

Studies

1. Studies of mucosal immunization for the induction of reciprocal protection against B. pertussis and B. parapertussis are under way in our laboratory.

Genome Sequences

1. Such studies are facilitated by the availability of genome sequences of B. bronchiseptica, B. pertussis, and B. parapertussis hu [ 10 ].

Whole Cells

1. We examined the antibody responses against whole cells of B. pertussis and of B. parapertussis by enzyme-linked immunosorbent assays.
2. Quantitation of antibodies against whole cells of B. pertussis and of B. parapertussis.
3. We examined the levels of IgG and IgA antibodies against whole cells of B. pertussis and of B. parapertussis.

Lungs

1. There were no significant differences between the CFU of B. pertussis or B. parapertussis recovered from the lungs of wild-type and TLR4-deficient mice (Fig. (Web site)
2. In B. parapertussis they are required for initial colonization of the lungs. (Web site)

Ptx

1. B. parapertussis and B. bronchiseptica synthesize virulence factors functionally and immunologically very close to B. pertussis, with the exception of PTX. (Web site)
2. For example, B. pertussis but not B. parapertussis hu expresses Ptx, although both contain the required genes.

Patients

1. The antibody responses of patients with pertussis to the surface polysaccharides of B pertussis and to B parapertussis were cross-reactive serologically. (Web site)
2. Two patients were positive for both B. pertussis and B. parapertussis. (Web site)
3. Our secondary hypothesis was that the prevalence of Bordetella parapertussis is also < 2% among these patients.

Milder Form

1. However, a closely related organism, B. parapertussis can also cause a milder form of bronchitis. (Web site)

Mice Infected

1. Adoptive transfer of spleen cells from mice infected with B. pertussis or B. parapertussis also failed to confer reciprocal protection.

Infections

1. Similar conclusions apply to the infections due to B. parapertussis or to B. bronchiseptica. (Web site)

Strains

1. The clonal structure of B. parapertussis is also confirmed by the results of the DNA macrorestriction digests by PFGE in the strains examined in this study. (Web site)
2. In contrast, this gene was detected in all B. pertussis, B. parapertussis hu, B. parapertussis ov, and B. bronchiseptica complex I strains. (Web site)

Avium

1. There are six additional species of Bordetella: B. parapertussis, B. bronchiseptica, B. avium, B. hinzii, B. holmesii, and B. trematum. (Web site)

Immunity

1. Again, immunity to B. pertussis did not protect against wild-type B. parapertussis (Fig.
2. After the transfer of spleen cells, the immunity of each mouse to B. pertussis and B. parapertussis was determined as described above.
3. However, immunity induced by B. pertussis infection prevented subsequent B. pertussis infections but did not protect against B. parapertussis infections. (Web site)

Bordetella Parapertussis

1. FIG. 8. Intranasal vaccination with AVS induces protective immunity against Bordetella pertussis and Bordetella parapertussis in the lower respiratory tract.
2. Clinical characteristics of illness caused by Bordetella parapertussis compared with illness caused by Bordetella pertussis.
3. Multiplex LightCycler PCR assay for detection and differentiation of Bordetella pertussis and Bordetella parapertussis in nasopharyngeal specimens. (Web site)

Categories

1. Life > Organisms > Bacteria > Pertussis
2. Bronchiseptica
3. Whooping Cough
4. Encyclopedia of Keywords > Society > Humans
5. Proteins > Antibodies > Antigens > Antigen

Related Keywords

* Antigen * Antigens * Bordetella * Bordetella Bronchiseptica * Bordetella Pertussis * Bronchiseptica * Disease * Humans * Lambs * Lps * Mice * Milder * Mouse Model * Pertussis * Pertussis Toxin * Protective Immunity * Respiratory Tract * Sheep * Virulence Factors * Whooping Cough

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