Definitions

1. Aplastic anemia is a rare but extremely serious disorder that results from the unexplained failure of the bone marrow to produce enough blood cells. (Web site)
2. Aplastic anemia is a rare disease that strikes the bone marrow and produces a deficiency of red blood cells, white blood cells and platelets.
3. Aplastic anemia (a-PLAS-tik uh-NEE-me-uh) is a blood disorder in which the body’s bone marrow doesn’t make enough new blood cells.
4. Aplastic anemia is a form of bone marrow failure that ranges in severity from mild to severe.
5. Aplastic anemia is a serious condition whereby bone marrow is unable to produce sufficient levels of red blood cells, white blood cells and platelets. (Web site)

Fanconi Anemia

1. For example, many people with Fanconi anemia who don't get aplastic anemia, will still go on to develop leukemia.

Congenital Anomalies

1. Fanconi anemia, also known as aplastic anemia with congenital anomalies, is a rare genetic disorder that may be apparent at birth or during childhood. (Web site)
2. Fanconi anemia is characterized by familial aplastic anemia, chromosomal breaks, and in some cases, congenital anomalies of the thumb or kidneys. (Web site)

People

1. Aplastic anemia (decreased production of blood cells) may lead to PNH, and people with PNH are at increased risk of acute myelogenous leukemia.
2. Blood and marrow stem cell transplants may offer a cure for some people who have aplastic anemia.
3. Some people may not have any symptoms, but results of a routine blood test may suggest a diagnosis of aplastic anemia.

Life-Threatening Illness

1. Aplastic anemia is a life-threatening illness. (Web site)

Severity

1. Treatment for aplastic anemia varies according to severity and cause. (Web site)
2. The severity of aplastic anemia of the patient was graded as non-severe aplastic anemia.
3. The outlook for aplastic anemia depends on its cause and severity, as well as the health and age of the patient. (Web site)

Fatal Cases

1. Aplastic anemia following viral hepatitis: report of two fatal cases and literature review.
2. Bone marrow toxicity was demonstrated in human cell cultures after the drug was released and produced more than 10,000 fatal cases of aplastic anemia. (Web site)

Cyclosporine

1. Antithymocyte globulin with or without cyclosporine A: 11-year follow-up of a randomized trial comparing treatments of aplastic anemia. (Web site)
2. Antithymocyte globulin and cyclosporine for severe aplastic anemia: association between hematologic response and long-term outcome. (Web site)
3. Antithymocyte globulin and cyclosporine for treatment of 44 children with hepatitis associated aplastic anemia. (Web site)

Overrepresented

1. For example, the null phenotype of certain glutathione transferases is overrepresented among patients with aplastic anemia. (Web site)

Transplantation

1. Aplastic anemia after liver transplantation for fulminant liver failure. (Web site)

Blood Dyscrasias

1. Carbamazepine carries a black box warning for blood dyscrasias, including agranulocytosis and aplastic anemia. (Web site)
2. The literature is now replete with case reports of aplastic anemia and other blood dyscrasias caused by benzene.

Complications

1. Half of the patients die of venous thrombosis or thrombopenic hemorrhage and others by the complications of aplastic anemia (AA). Ca. (Web site)
2. Most people with aplastic anemia require repeated transfusions, which can lead to complications.
3. The goals of pharmacotherapy in cases of aplastic anemia are to reduce morbidity, prevent complications, and eradicate malignancy.

Clonality

1. Young NS. The problem of clonality in aplastic anemia: Dr. Dameshek's riddle, restated.

Pnh Cells

1. Some patients have small numbers of PNH cells when they are diagnosed with aplastic anemia.

Cytopenias

1. None of the patients with acquired aplastic anemia, acquired cytopenias, or in the control group showed overexpression of p53 protein.
2. We also explored the possibility that asymptomatic muta- tion carriers with short telomeres had cytopenias that reflected early changes of aplastic anemia.

Mild Cases

1. Mild cases of aplastic anemia may be treated with supportive care or may require no treatment. (Web site)

Acute Viral Hepatitis

1. Aplastic anemia is present in up to 2% of patients with acute viral hepatitis. (Web site)
2. Unusual and sometimes fatal complications of acute viral hepatitis include aplastic anemia, hemolytic anemia, hypoglycemia, and polyarteritis. (Web site)

Bleeding

1. People with severe or very severe aplastic anemia are at risk for life-threatening infections or bleeding. (Web site)
2. Patients with aplastic anemia produce too few blood cells, causing fatigue, easy bruising and bleeding, and susceptibility to infections. (Web site)
3. For a person with severe or very severe aplastic anemia, infections or bleeding can be life-threatening. (Web site)

Ticlopidine

1. Ticlopidine is occasionally associated with thrombocytopenia unrelated to TTP or aplastic anemia. (Web site)
2. Severe aplastic anemia induced by ticlopidine: report of two cases. (Web site)

Bone Marrow Failure

1. Bone marrow failure typically manifests with neutropenia, but anemia, thrombocytopenia, or aplastic anemia may also develop.
2. Fanconi anemia (FA) is one of the inherited anemias that leads to bone marrow failure (aplastic anemia).
3. One possible complication is bone marrow failure which results in significant under-production of all blood cells (aplastic anemia).

Paul Ehrlich

1. Paul Ehrlich introduced the concept of aplastic anemia in 1888 when he studied the case of a pregnant woman who died of bone marrow failure.

Orthotopic

1. Tacrolimus (FK506) in allogeneic bone marrow transplantation for severe aplastic anemia following orthotopic liver transplantation. (Web site)
2. Severe aplastic anemia (SAA) is a frequent complication of orthotopic liver transplantation for non-typeable viral hepatitis. (Web site)

Non-A

1. We conclude that patients undergoing orthotopic liver transplantation for non-A, non-B hepatitis are at a high risk for the development of aplastic anemia. (Web site)

Pathogenesis

1. This topic will review the pathogenesis, etiology, clinical manifestations, and diagnosis of aplastic anemia [ 3].

Doctor

1. Your doctor will do a physical exam to check for signs of aplastic anemia.
2. If any of the symptoms described above for neutropenia, TTP, aplastic anemia or jaundice occur, contact your doctor immediately. (Web site)
3. To further aid in the diagnosis of aplastic anemia, your doctor will also need to examine a sample of your bone marrow under a microscope. (Web site)

Anti-Thymocyte Globulin

1. Long term outcome of aplastic anemia in adults treated with anti-thymocyte globulin: Comparison with bone marrow transplantation.
2. Epstein-Barr virus reactivation in a patient treated with anti-thymocyte globulin for severe aplastic anemia. (Web site)

Bone Marrow Transplant

1. Treatment for aplastic anemia may include medications, blood transfusions or a bone marrow transplant. (Web site)
2. Bone marrow transplant is an effective treatment for some people with aplastic anemia. (Web site)
3. In cases of severe aplastic anemia, a bone marrow transplant is the treatment of choice. (Web site)

Bone Marrow Transplants

1. When a person has a blood disease, such as aplastic anemia or leukemia, doctors may perform bone marrow transplants to re-establish a healthy blood supply. (Web site)
2. Bone marrow transplants are done in special units in hospitals to try to protect the person with aplastic anemia from any infections. (Web site)
3. Bone marrow transplants from mismatched related and unrelated donors for severe aplastic anemia. (Web site)

Red Blood Cells

1. Blood transfusions Most people with aplastic anemia require multiple blood transfusions - transfusions of red blood cells or platelets, or both.
2. Transfusions of red blood cells are often needed for the temporary relief of anemia in patients with aplastic anemia. (Web site)
3. Aplastic Anemia: Anemia caused by failure of red blood cells to regenerate. (Web site)

Producing Blood Cells

1. Aplastic anemia is a form of anemia where the bone marrow stops producing blood cells. (Web site)
2. Felbatol has caused serious liver damage and aplastic anemia, a condition in which the bone marrow stops producing blood cells. (Web site)

Therapy

1. Only a few cases of neutropenia, TTP, or aplastic anemia have arisen after more than 3 months of therapy. (Web site)
2. This article reviews the key diagnostic and prognostic factors that influence the choice of therapy in patients with acquired aplastic anemia.
3. High-dose cyclophosphamide is highly effective therapy for severe aplastic anemia. (Web site)

Methylprednisolone

1. Treatment of aplastic anemia with antilymphocyte globulin and methylprednisolone with or without cyclosporine.

Acute Leukemia

1. Acute leukemia (including ALL, AML and myelodysplastic syndrome) and aplastic anemia accounted for 21 per cent and 20 per cent cases respectively. (Web site)
2. Bone marrow transplantation in adults in acute leukemia, aplastic anemia and paroxysmal nocturnal hemoglobinuria. (Web site)
3. Another problem is that, occasionally, people with aplastic anemia go on to develop acute leukemia.

Allogeneic Marrow Transplantation

1. Excellent long-term survival after allogeneic marrow transplantation in patients with severe aplastic anemia. (Web site)

Myelodysplastic Syndrome

1. Many cases of aplastic anemia go into remission, but some cases progress to myelodysplastic syndrome and acute myeloid leukemia. (Web site)
2. Risk factors for evolution of acquired aplastic anemia into myelodysplastic syndrome and acute myeloid leukemia after immunosuppressive therapy in children. (Web site)
3. Increased risk for aplastic anemia and myelodysplastic syndrome in individuals lacking glutathione S-transferase genes. (Web site)

Monosomy

1. Long-term administration of G-CSF for aplastic anemia is closely related to the early evolution of monosomy 7 MDS in adults. (Web site)
2. Pathogenesis of monosomy 7 and its relation to aplastic anemia is discussed. (Web site)

Immune System

1. Aplastic anemia that occurs in pregnancy may be related to an autoimmune problem - your immune system may attack your bone marrow during pregnancy. (Web site)
2. Medicines that suppress the immune system do not cure aplastic anemia, but they can relieve its symptoms and reduce its complications. (Web site)
3. Antibiotics, antivirals Having aplastic anemia weakens your immune system. (Web site)

Immunosuppressive Drugs

1. Aplastic anemia is treated with blood transfusions, immunosuppressive drugs, or stem cell transplants.
2. Drug therapy is also used to treat aplastic anemia, and the two most common types of drugs used are immunosuppressive drugs and growth factors. (Web site)
3. The two immunosuppressive drugs most frequently used to treat aplastic anemia are antithymocyte globulin (ATG) and cyclosporine. (Web site)

Cyclosporine Therapy

1. Quality of hematologic recovery in patients with aplastic anemia following cyclosporine therapy.
2. HLA DR2: a predictive marker in response to cyclosporine therapy in aplastic anemia. (Web site)

Good Response

1. Still, even among those patients who have a good response, many later suffer a relapse (return) of aplastic anemia. (Web site)
2. Interferon-gamma gene expression in unstimulated bone marrow mononuclear cells predicts a good response to cyclosporine therapy in aplastic anemia. (Web site)
3. If being treated for aplastic anemia, it may take a long time to get a good response from the treatment.

Growth Factors

1. Growth factors may work well in combination with each other or with immune-suppressing drugs to relieve the signs and symptoms of aplastic anemia. (Web site)
2. A person with aplastic anemia may be given growth factors to try to reduce the need for red blood cell transfusions.
3. In some cases, treatment of refractory aplastic anemia with growth factors had led to clinically beneficial improvement in blood cell counts.

Hematopoietic Stem Cells

1. In aplastic anemia, a precipitating event (usually immune-mediated) leads to the nearly complete destruction of hematopoietic stem cells.
2. Acquired severe aplastic anemia is a rare disease characterized by an immune-mediated functional impairment of hematopoietic stem cells. (Web site)
3. In most instances, aplastic anemia results from damage to hematopoietic stem cells. (Web site)

Risk

1. Patients with aplastic anemia are at risk for life-threatening infections or bleeding. (Web site)
2. Until blood cell counts return to normal, someone who has aplastic anemia is at risk for infection, bleeding, and other complications. (Web site)
3. Aplastic anemia may not manifest itself for months and patients may remain at risk for an undetermined amount of time after treatment is stopped. (Web site)

Low Blood Cell Counts

1. Aplastic anemia can cause signs and symptoms that aren’t directly related to low blood cell counts.
2. Severe aplastic anemia, as evidenced by very low blood cell counts, is a life-threatening condition. (Web site)

Stem Cell Transplant

1. Children with inherited causes of aplastic anemia are treated with supportive therapy (such as androgens) and stem cell transplant.
2. In aplastic anemia, this stem cell transplant is successful up to 80% to 90% of the time if cells from a matched related donor are used.
3. Those with acquired aplastic anemia are treated with supportive care, followed by immunesuppressant therapy or stem cell transplant.

Stem Cell Transplants

1. It is currently being used as a part of stem cell transplants, and is under study as a treatment for aplastic anemia.
2. Serious anemia, such as aplastic anemia, that results from the failure of bone marrow to make RBCs is sometimes treated with marrow or stem cell transplants. (Web site)
3. Stem cell transplants are usually reserved for people with severe aplastic anemia and are most successful in children and young adults with matched donors.

Drugs

1. Aplastic anemia may also be caused by certain medical conditions (such as pregnancy or lupus) or exposure to some toxins or drugs (including chemotherapy). (Web site)
2. Agranulocytosis and aplastic anemia are rare but serious blood diseases that can be caused by drugs and other environmental factors. (Web site)
3. Several agents including drugs, chemicals and viruses are known to induce agranulocytosis, aplastic anemia, and leukemia. (Web site)

Categories

1. Bone Marrow
2. Humans > Health > Diseases > Patients
3. Anatomy > Tissues > Blood > Blood Cells
4. Anatomy > Tissues > Blood > Anemia
5. Health > Diseases > Treatments > Treatment

Related Keywords

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