Definitions

1. Terbinafine hydrochloride is a synthetic allylamine derivative.
2. Terbinafine hydrochloride is a white to off- white fine crystalline powder.
3. Terbinafine hydrochloride is a white to off-white fine crystalline powder.

Terbinafine Hydrochloride

1. Chemically, terbinafine hydrochloride is (E)-N-(6,6-dimethyl-2-hepten-4-ynyl)-N-methyl-1- naphthalenemethanamine hydrochloride.
2. Lamisil® (terbinafine hydrochloride tablets) Tablets contain the synthetic allylamine antifungal compound terbinafine hydrochloride.
3. Changes in the ocular lens and retina have been reported following the use of Lamisil (terbinafine hydrochloride tablets) Tablets in controlled trials.
4. Treatment with Terbinafine hydrochloride is not recommended in nursing mothers.
5. The safety and efficacy of Terbinafine hydrochloride have not been established in pediatric patients.

Discontinued

1. Clinical experience regarding overdose with Lamisil ® (terbinafine hydrochloride) Tablets is limited.
2. If progressive skin rash occurs, treatment with Terbinafine hydrochloride should be discontinued.
3. Terbinafine hydrochloride therapy should be discontinued in patients with clinical signs and symptoms suggestive of lupus erythematosus.

Discontinuation

1. These were reversible upon discontinuation of Terbinafine hydrochloride, with or without supportive therapy.
2. Terbinafine hydrochloride may cause taste disturbance (including taste loss), which usually recovers within several weeks after discontinuation of the drug.

Liver Disease

1. Lamisil ® (terbinafine hydrochloride) Tablets are not recommended for patients with chronic or active liver disease.
2. Before prescribing Terbinafine hydrochloride tablets, pre-existing liver disease should be assessed.

Antifungal

1. Lamisil Cream contains the synthetic antifungal agent terbinafine hydrochloride.
2. Terbinafine hydrochloride is fungicidal against dermatophytes, moulds and certain dimorphous fungi.
3. Depending on the concentration of the drug and the fungal species test in vitro, terbinafine hydrochloride may be fungicidal.
4. Terbinafine hydrochloride produces its antifungal activity by inhibiting squalene epoxidase, an enzyme that is important to the biosynthesis of ergosterol.

Mg Tablet

1. Lamisil ® (terbinafine hydrochloride) Tablets, one 250 mg tablet, should be taken once daily for 6 weeks by patients with fingernail onychomycosis.
2. Terbinafine hydrochloride, one 250 mg tablet, should be taken once daily for 12 weeks by patients with toenail onychomycosis.
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