Definitions

1. Cyclophosphamide is a chemotherapy drug that can suppress the immune system and damage T-lymphocytes.
2. Cyclophosphamide is a chemotherapy drug that also has potent immune suppressing qualities.
3. Cyclophosphamide is a synthetic antineoplastic drug chemically related to the nitrogen mustards. (Web site)
4. Cyclophosphamide (Cytoxan) is another drug that may be used in certain circumstances.
5. Cyclophosphamide is itself carcinogenic, potentially causing transitional cell carcinoma of the bladder as a long-term complication. (Web site)

Cyclophosphamide Therapy

1. Two years after receiving the cyclophosphamide therapy, 73 percent of patients no longer required blood transfusions. (Web site)

High Dose Cyclophosphamide

1. OBJECTIVES: I. Confirm the efficacy demonstrated in a pilot study using high dose cyclophosphamide in patients with severe aplastic anemia. (Web site)

High-Dose Cyclophosphamide Therapy

1. Objective: To confirm the safety and efficacy of high-dose cyclophosphamide therapy alone in patients with severe aplastic anemia.

High-Dose Cyclophosphamide

1. Newer methods of treatment, including high-dose cyclophosphamide and the development of potentially tolerizing combinations of drugs. (Web site)
2. High-Dose Cyclophosphamide uses chemotherapy to treat the occurrence of harmful lymphocytes that destroy blood cells produced by the bone marrow.

Limited

1. In one embodiment, the anti-cancer chemotherapeutic agent is an alkylating agent, such as but not limited to cyclophosphamide. (Web site)

Active

1. Trofosfamide is an alkylating agent related to cyclophosphamide, active by oral route, used in the treatment of lymphomas. (Web site)

Vomiting

1. Cyclophosphamide commonly causes nausea, vomiting and hair loss and can affect the heart, lungs and liver.
2. Nausea and vomiting commonly occur with cyclophosphamide therapy. (Web site)

Results

1. RESULTS: After 12 months of treatment, two of five patients experienced a complete response with high-dose cyclophosphamide therapy.
2. The results appear to be due to the G-CSF-induced priming after high-dose cyclophosphamide.

Whether

1. II. Determine whether the addition of filgrastim (G-CSF) to high dose cyclophosphamide shortens the time to recovery in these patients. (Web site)

Impact

1. Impact of five prophylactic filgrastim schedules on hematologic toxicity in early breast cancer patients treated with epirubicin and cyclophosphamide.

Sclerosis

1. Reduction of disease activity and disability with high-dose cyclophosphamide in patients with aggressive multiple sclerosis. (Web site)

Stem Cells

1. Thus, stem cells of the high quality pool are resistant to cyclophosphamide. (Web site)

Effect

1. The same effect was seen with cyclophosphamide.

Mice

1. The administration of cyclophosphamide, a strong immunosuppressant, produced a side effect in the form of a reduction in the body weight of the mice. (Web site)

Neutropenia

1. Other groups investigating the impact of neutropenia on pneumococcal infection have used cyclophosphamide.

Conditioning

1. TBI-containing conditioning was associated with a higher mortality and responses tended to be better when conditioning included cyclophosphamide.

Immunosuppression

1. For example, that agent might be cyclophosphamide that causes immunosuppression. (Web site)

Risk

1. Your risk for bladder cancer may be increased if you have received the chemotherapy drugs Cytoxan (cyclophosphamide) or Ifex or Isophosphamide (ifosfamide).
2. However, combining fludarabine with rituximab and cyclophosphamide may reduce that risk [ 4].

Allogeneic Bone Marrow Transplantation

1. Allogeneic bone marrow transplantation after hyperfractionated total-body irradiation and cyclophosphamide in children with acute leukemia. (Web site)
2. Addition of low-dose busulfan to cyclophosphamide in aplastic anemia patients prior to allogeneic bone marrow transplantation to reduce rejection. (Web site)
3. High-dose cyclophosphamide therapy followed by allogeneic bone marrow transplantation cures the disease.

Cells

1. Giving fludarabine and cyclophosphamide together with rituximab may kill more cancer cells. (Web site)

Chronic Lymphocytic Leukemia

1. Cladribine combined with cyclophosphamide is highly effective in the treatment of chronic lymphocytic leukemia. (Web site)
2. Assessment of fludarabine plus cyclophosphamide for patients with chronic lymphocytic leukemia (the LRF CLL4 trial): a randomized controlled trial. (Web site)

Aplastic Anemia

1. Brodsky RA. High-dose cyclophosphamide for aplastic anemia and autoimmunity. (Web site)

Bone Marrow Transplantation

1. Pregnancies following high-dose cyclophosphamide with or without high-dose busulfan or total-body irradiation and bone marrow transplantation. (Web site)
2. Conclusions: High-dose cyclophosphamide therapy without bone marrow transplantation produces durable treatment-free remission in severe aplastic anemia. (Web site)
3. Brown RA, Herzig RH, Wolff SN, et al.: High-dose etoposide and cyclophosphamide without bone marrow transplantation for resistant hematologic malignancy. (Web site)

Plasma Exchange

1. The Canadian cooperative trial of cyclophosphamide and plasma exchange in progressive multiple sclerosis.
2. A randomized, three-arm study of high-dose intravenous cyclophosphamide, plasma exchange, and ACTH. N Engl J Med 1983; 308:173.

Chronic Lymphocytic Leukaemia

1. Assessment of fludarabine plus cyclophosphamide for patients with chronic lymphocytic leukaemia (the LRF CLL4 Trial): a randomised controlled trial. (Web site)

Initial Therapy

1. The cause is unknown and glucocorticoids are usually effective initial therapy; some patients require cyclophosphamide.

Patient

1. Our patient was on cyclophosphamide at the time of diagnosis, the use of which is known to be associated with hypogonadism. (Web site)
2. Only one patient did not achieve significant reduction in the alloantibody titer after high-dose cyclophosphamide. (Web site)

Anti-Thymocyte Globulin

1. The preparative regimen for the second BMT consisted of fludarabine, cyclophosphamide, and anti-thymocyte globulin. (Web site)

Severe Aplastic Anaemia

1. High-dose cyclophosphamide in severe aplastic anaemia: a randomised trial.
2. High dose cyclophosphamide in severe aplastic anaemia: a randomised trial. (Web site)

Pentostatin

1. Shanafelt TD, Lin T, Geyer SM, et al.: Pentostatin, cyclophosphamide, and rituximab regimen in older patients with chronic lymphocytic leukemia. (Web site)

Alkylating Agents

1. Chemotherapy with alkylating agents, such as cyclophosphamide, mechlorethamine, procarbazine, and ifosfamide.
2. The agents most often associated with infertility are the alkylating agents such as cyclophosphamide.

Etoposide

1. High-dose fractionated total-body irradiation, etoposide, and cyclophosphamide followed by autologous stem-cell support in patients with malignant lymphoma. (Web site)

Mitoxantrone

1. Cladribine combined with cyclophosphamide and mitoxantrone as front-line therapy in chronic lymphocytic leukemia.

Conditioning Regimen

1. Long-term outcome after bone marrow transplantation for aplastic anemia using cyclophosphamide and total lymphoid irradiation as conditioning regimen.
2. Conditioning regimen consisted of cyclophosphamide combined with antithymocyte globulin in all patients.

Body Irradiation

1. All patients received total body irradiation with either Ara-C or thiotepa and cyclophosphamide. (Web site)
2. Unrelated donor marrow transplantation in children with severe aplastic anaemia using cyclophosphamide, anti-thymocyte globulin and total body irradiation. (Web site)

Vincristine

1. If the pheochromocytoma is a cancer that has spread, chemotherapy with cyclophosphamide, vincristine, and dacarbazine may help slow the tumor's growth. (Web site)
2. Malignant Schwannomas are treated with chemotherapeutic agents, including vincristine, adriamycin, cyclophosphamide and imidazole carboxamide. (Web site)

Cytoxan

1. Other medications to suppress the immune system, such as cyclosporine, tacrolimus, and cyclophosphamide (Cytoxan) also may be used. (Web site)
2. Cyclophosphamide (Cytoxan) used to be considered the gold standard of treatment for lupus kidney disease (lupus nephritis). (Web site)
3. An anthracycline drug, such as daunorubicin (Cerubidine), used for reinduction followed by cyclophosphamide (Cytoxan, Neosar) 3 months after remission. (Web site)

Effects

1. Effects of cyclophosphamide on the development of malignancy and on long term survival of patients with rheumatoid arthritis. (Web site)

High Doses

1. The researchers report that treatment with high doses of cyclophosphamide eliminates the abnormal immune system. (Web site)

Busulfan

1. To check that idea, the team treated mice with two chemotherapy drugs that cause infertility, cyclophosphamide and busulfan.
2. Stem cell and bone marrow transplants that include total-body irradiation (TBI), cyclophosphamide, or busulfan may damage the ovaries.

Marrow Transplantation

1. Marrow transplantation for acute nonlymphocytic leukemia after treatment with busulfan and cyclophosphamide. (Web site)
2. High-dose cytarabine and total body irradiation with or without cyclophosphamide as a preparative regimen for marrow transplantation for acute leukemia.

Combination

1. Wu LT, Averbuch SD, Ball DW, et al.: Treatment of advanced medullary thyroid carcinoma with a combination of cyclophosphamide, vincristine, and dacarbazine.
2. Fludarabine has been used in combination with busulfan or cyclophosphamide to prepare children with a variety of marrow stem cell disorders.
3. In allogeneic transplants a combination of cyclophosphamide with busulfan or total body irradiation is commonly employed. (Web site)

Antithymocyte Globulin

1. The initial drug regimen includes antithymocyte globulin, often in combination with cyclosporine A, followed by moderate-dose steroids and cyclophosphamide.
2. Fludarabine, cyclophosphamide, and antithymocyte globulin for a patient with dyskeratosis congenita and severe bone marrow failure. (Web site)
3. Cyclophosphamide combined with antithymocyte globulin in preparation for allogeneic marrow transplants in patients with aplastic anemia. (Web site)

Saa

1. High-dose cyclophosphamide has been used successfully in the treatment of adults with SAA, but experience in children is limited.

Patients

1. Recently, results of immunosuppression in SAA with another potent immunosuppressive agent, cyclophosphamide, were reported in 10 patients. (Web site)
2. Cyclophosphamide and antithymocyte globulin to condition patients with aplastic anemia for allogeneic marrow transplantation: the experience in four centers. (Web site)
3. Methylprednisolone and cyclophosphamide, alone or in combination, in patients with lupus nephritis.

Alemtuzumab

1. Marrow transplants from matched unrelated donors for aplastic anaemia using alemtuzumab, fludarabine and cyclophosphamide based conditioning. (Web site)
2. The usefulness of other immunosuppressive drugs, including cyclophosphamide, rapamycin and alemtuzumab, is currently being researched. (Web site)

Categories

1. Fludarabine
2. Encyclopedia of Keywords > Time > Rituximab
3. Severe Aplastic Anemia
4. Bone Marrow Transplantation
5. Anatomy > Tissues > Blood > Chronic Lymphocytic Leukemia

Related Keywords

* Atg * Azathioprine * Chemotherapy * Cisplatin * Cyclosporine * Doxorubicin * Drug * Drugs * Fludarabine * Methotrexate * Prednisone * Rituximab * Severe Aplastic Anemia * Treatment

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