Definitions

1. Propylthiouracil (PTU) is a thionamide drug used to treat hyperthyroidism by decreasing the amount of thyroid hormone produced by the thyroid gland.
2. Propylthiouracil (PTU) is the most commonly used drug to treat hyperthyroidism during pregnancy.
3. Propylthiouracil is an antithyroid drug administered orally.
4. Propylthiouracil is considered second-line drug therapy, except in certain patients who are allergic to, or intolerant of, methimazole.
5. Propylthiouracil is in the FDA pregnancy category D. This means that propylthiouracil is known to be harmful to an unborn baby.

Patient

1. The patient has been given an antithyroid drug called propylthiouracil.

Serious

1. In rare cases, propylthiouracil has caused serious liver problems.

Damage

1. Hepatitis (liver damage)-This is seen more often with propylthiouracil than with methimazole.

Platelets

1. Rarely, propylthiouracil can affect the blood causing decreased levels of red and white blood cells and platelets.

Blocking

1. Additionally, propylthiouracil acts by blocking the conversion of T 4 to T 3 in the peripheral tissues.

Health

1. Health Rarely, propylthiouracil can affect the blood causing decreased levels of red and white blood cells and platelets.

Day

1. The dose of propylthiouracil was reduced to 25 mg four times per day, and the patient was advised that she could start trying to conceive.

Hormone Therapy

1. GENERALLY AVOID: Antithyroid agents such as methimazole and propylthiouracil can affect the therapeutic response to thyroid hormone therapy.

Purposes

1. Propylthiouracil may also be used for purposes other than those listed here.

Medication Guide

1. Propylthiouracil may also be used for other purposes not listed in this medication guide.

Pregnant Woman

1. Propylthiouracil can cause fetal harm when administered to a pregnant woman.

Benefit

1. It is important to take propylthiouracil regularly to get the most benefit.

Symptoms

1. Propylthiouracil may also cause severe liver symptoms.

Hormone Production

1. The two primary medications used to limit thyroid hormone production are methimazole and propylthiouracil (PTU).

Iodine

1. In 2004, some drugs used to interfere with the thyroid gland's uptake of iodine were propylthiouracil (PTU) and methimazole (Tapazole®).
2. Administer an antithyroid drug, such as propylthiouracil or methimazole, and large amounts of iodine to decrease thyroid hormone production.

Hormone Synthesis

1. Propylthiouracil and methimazole are two agents that decrease thyroid hormone synthesis and are usually prescribed in fairly high doses.
2. It is safer and more potent than propylthiouracil in blocking thyroid hormone synthesis.

Over-Active

1. Propylthiouracil is used to treat a condition known as hyperthyroidism (over-active thyroid).

Nursing Baby

1. Propylthiouracil passes into breast milk and may affect a nursing baby.

Subtotal Thyroidectomy

1. Subtotal thyroidectomy is indicated in pregnant patients and children who have a major adverse reaction to propylthiouracil or methimazole.

Treat Hyperthyroidism

1. Propylthiouracil is used to treat hyperthyroidism, especially in women during pregnancy.
2. Propylthiouracil is used to treat hyperthyroidism (over-active thyroid).

Iodides

1. Goitrogenic drugs include propylthiouracil, methimazole, iodides, and lithium.

Antithyroid Medications

1. Administer antithyroid medications (propylthiouracil [PTU]) that block thyroid synthesis, as prescribed.
2. The simplest and least invasive way to treat hyperthyroidism is through taking antithyroid medications, like propylthiouracil and methimazole.

Carbimazole

1. Antithyroid drugs include thiouracil, propylthiouracil, methimazole, carbimazole, potassium perchlorate, and thiocyanate.
2. Carbimazole and Propylthiouracil do not affect the release of preformed thyroid hormone so take weeks to act.
3. Graves' disease may be treated with the thioamide drugs propylthiouracil, carbimazole or methimazole, or rarely with Lugol's solution.

Tapazole

1. Propylthiouracil and methimazole (Tapazole) are the two antithyroid drugs used in the United States [and Canada].
2. More severe hyperthyroidism is treated with propylthiouracil or sometimes methimazole (Tapazole), drugs that interfere with thyroid hormone production.
3. Therefore, you will take either propylthiouracil or Tapazole to lower your thyroid hormone levels.

Gland

1. Rarely, surgery to remove all or part of the thyroid gland is considered for women who cannot tolerate propylthiouracil or methimazole.

Thyroxin

1. In large doses, propylthiouracil also inhibits the peripheral tissue conversion of thyroxin to triiodothyrominine.

Patients

1. If patients develop a fever, a sore throat, or any signs of infection while taking methimazole or propylthiouracil, they should see a doctor immediately.
2. Rectal administration of propylthiouracil in suppository form in patients with thyrotoxicosis and critical illness: case report and review of literature.
3. Thus, propylthiouracil has been tested in randomized clinical trials in patients with alcohol-induced liver disease.

Doctor

1. Initially, the doctor will prescribe either methimazole (Tapazole) or propylthiouracil (PTU) pills which are antithyroid agents.
2. FDA pregnancy category D. Do not use propylthiouracil without telling your doctor if you are pregnant.
3. But, if you are in your first trimester of pregnancy or if you cannot take methimazole, your doctor may have you take propylthiouracil.

Medications

1. If patients are taking propylthiouracil or methimazole, encourage them to take the medications with meals to limit gastric irritation.

Treatment

1. Comparison of single daily dose of methimazole and propylthiouracil in the treatment of Graves' hyperthyroidism.
2. Treatment with propylthiouracil, 5 to 10 mg per kg per day, or methimazole, 0.5 mg per kg per day is the standard.
3. Yeung SC, et al.: Rectal administration of iodide and propylthiouracil in the treatment of thyroid storm.

Radioactive Iodine

1. Treated with antithyroid drugs (propylthiouracil, methimazole, radioactive iodine).
2. Hyperthyroidism may be treated with antithyroid meds (Methimazole, Propylthiouracil), radioactive iodine or surgery.

Hormone

1. Propylthiouracil prevents the thyroid gland from producing too much thyroid hormone.
2. Antithyroid medications, including methimazole (Tapazole) and propylthiouracil, work by slowing down the thyroid hormone and restoring normal levels.
3. Propylthiouracil or methimazole (Tapazole) are the usual first-line agents to block the synthesis of thyroid hormone.

Hormones

1. Antithyroid medications (such as methimazole and propylthiouracil) that reduce production of thyroid hormones also are prescribed.
2. These prescription medications, including propylthiouracil and methimazole (Tapazole), prevent your thyroid from producing excessive amounts of hormones.
3. Propylthiouracil inhibits the synthesis of thyroid hormones and thus is effective in the treatment of hyperthyroidism.

Drug

1. On a weight basis, the drug is at least 10 times as potent as propylthiouracil, but methimazole may be less consistent in action.
2. The damage is reversible once use of the drug stops, unlike with propylthiouracil.

Drugs

1. Up to 50% of patients who are taking methimazole or carbimazole and propylthiouracil develop cross-reactivity with the drugs.
2. Thyrostatics are drugs that inhibit the production of thyroid hormones, such as carbimazole (used in UK) and methimazole (used in US), and propylthiouracil.
3. In the United States, two drugs are available for treating hyperthyroidism: propylthiouracil (PTU) and methimazole (Tapazole).

Breast-Feeding

1. You should not use this medication if you are allergic to propylthiouracil, or if you are breast-feeding a baby.

First Talking

1. Do not take propylthiouracil without first talking to your doctor if you are breast-feeding a baby.
2. Do not use propylthiouracil without first talking to your doctor if you are pregnant or could become pregnant during treatment.

Overactive

1. Doctors usually first try either propylthiouracil or methimazole to treat children with Graves' disease, the most common cause of an overactive thyroid.

Hyperthyroidism

1. DRUG CLASS AND MECHANISM: Propylthiouracil (PTU) is used to manage hyperthyroidism which is due to an overactive thyroid gland.
2. Single daily dose of methimazole compared to every 8 hours propylthiouracil in the treatment of hyperthyroidism.
3. Propylthiouracil may also be used to ameliorate hyperthyroidism in preparation for subtotal thyroidectomy of radioactive iodine therapy.

Ptu

1. Examples are propylthiouracil (PTU), methimazole (Tapazole®), and carbimazole.
2. Antithyroid medications in current use in North America include propylthiouracil (PTU) and methimazole (Tapazole).
3. Medications used to treat hyperthyroidism, such as propylthiouracil (PTU) and methimazole, may increase the risk of hypothyroidism.

Methimazole

1. Hyperthyroidism can be treated with antithyroid medications such as propylthiouracil (Propyl-Thyracil) or methimazole (Tapazole).
2. Anti-thyroid drugs (carbimazole, methimazole, and propylthiouracil) restore euthyroidism within a few weeks of initiation of treatment [ 4].
3. The most commonly used medications are propylthiouracil (Propacil, PTU) and methimazole (Tapazole) until patient is euthyroid.

Propylthiouracil

1. Some people with hyperthyroidism receive antithyroid drugs such as propylthiouracil (PTU) or methimazole (Tapazole).
2. Hyperthyroidism may be treated with anti-thyroid drugs like methimazole and propylthiouracil (PTU) - which block the thyroid from producing thyroid hormone.
3. Two antithyroid drugs, methimazole and propylthiouracil (PTU), interfere with the way the thyroid gland uses iodine to make thyroid hormones.

Categories

1. Humans > Medicine > Drugs > Methimazole
2. Ptu
3. Animals > Felines > Cats > Hyperthyroidism
4. Graves' Disease
5. First Talking
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