Essential Gene

1. The PIG-A gene has been shown to be an essential gene in various eukaryotes.

Japanese Patients

1. CD59-deficient blood cells and PIG-A gene abnormalities in Japanese patients with aplastic anaemia.

Deficiency

1. Deficiency of the GPI anchor caused by a somatic mutation of the PIG-A gene in paroxysmal nocturnal hemoglobinuria.

Abnormality

1. People are not born with an altered PIG-A gene, probably because such an abnormality would be lethal to an unborn child.

Gene

1. PIG-A gene - The gene that is in charge of making a protective shield of proteins on normal red blood cells.

Cases

1. In almost all cases so far the defect could be attributed to a somatic mutation in the PIG-A gene (6,7).

Genetic Changes

1. Genetic changes were detected in the PIG-A gene in 5 of 13 cases analyzed.

Gpi

1. Spontaneous somatic mutations are common in the PIG-A gene, leading to failure of synthesis of the glycosyl phosphatidylinositol (GPI) anchor.

Mutations

1. Resistance to apoptosis caused by PIG-A gene mutations in paroxysmal nocturnal hemoglobinuria.

Paroxysmal Nocturnal Haemoglobinuria

1. PIG-A gene mutations in four Taiwanese patients with paroxysmal nocturnal haemoglobinuria following aplastic anaemia.

Pnh

1. Identification of three novel mutations in the PIG-A gene in paroxysmal nocturnal haemoglobinuria (PNH) patients.
2. Kinoshita successfully identified the defect in PNH as mutations in the PIG-A gene, which interrupt the first step in GPI synthesis.
3. Kinoshita and his group first cloned the pig-a gene, which was subsequently found to be mutated in all cases of PNH reported to date.

Somatic Mutations

1. Somatic mutations of the PIG-A gene found in Japanese patients with paroxysmal nocturnal hemoglobinuria.

Paroxysmal Nocturnal Hemoglobinuria

1. Ware RE, Rosse WF, Howard TA. Mutations within the Pig-a gene in patients with paroxysmal nocturnal hemoglobinuria.
2. A rare clonal hematopoietic stem cell disease, paroxysmal nocturnal hemoglobinuria (PNH), is caused by mutations in the PIG-A gene.
3. Paroxysmal nocturnal hemoglobinuria (PNH) occurs because of a change (mutation) in the PIG-A gene of a single stem cell in the bone marrow.

Pig-A Gene

1. Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired clonal disease of hematopoiesis due to a mutation in the PIG-A gene.
2. Paroxysmal nocturnal haemoglobinuria (PNH) is caused by somatic mutations in the PIG-A gene.
3. Paroxysmal nocturnal hemoglobinuria (PNH) is caused by somatic mutations in the PIG-A gene.

Categories

1. Paroxysmal Nocturnal Hemoglobinuria
2. Somatic Mutations
3. Pnh
4. Paroxysmal Nocturnal Haemoglobinuria
5. Hematopoiesis
6. Books about "Pig-A Gene" in Amazon.com
   

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